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Inventi Impact: Molecular Pharmacology

Articles

  • Inventi:pmp/44663/22
    Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells
    01-Apr-2022 Research 2022 : April-June
    Rodrigo Santos Aquino de Araújo, Julianderson de Oliveira dos Santos Carmo, Simone Lara de Omena Silva, Camila Radelley Azevedo Costa da Silva, Tayhana Priscila Medeiros Souza, Natália Barbosa de Mélo, Jean-Jacques Bourguignon, Martine Schmitt, Thiago Mendonça de Aquino, Renato Santos Rodarte, Ricardo Olímpio de Moura, José Maria Barbosa Filho, Emiliano Barreto, Francisco Jaime Bezerra Mendonça-Junior

    A series of coumarin derivatives and isosteres were synthesized from the reaction of triflic intermediates with phenylboronic acids, terminal alkynes, and organozinc compounds through palladium-catalyzed cross-coupling reactions. The in vitro cytotoxic effect of the compounds was evaluated against two non-small cell lung carcinoma (NSCLC) cell lines (A-549 and H2170) and a normal cell line (NIH-3T3) using cisplatin as a reference drug. Additionally, the effects of the most promising coumarin derivative (9f) in reversing the epithelial-to-mesenchymal transition .................

    How to Cite this Article
    Attribution/ CC Compliant Citation: de Araújo, Rodrigo Santos Aquino, et al. "Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial -Mesenchymal Transition and Migration in A549 Cells." Pharmaceuticals 15.1 (2022): 104. https://doi.org/10.3390/ph15010104 http://creativecommons.org/licenses/by/4.0/ Some formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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